<div><p>Cytochrome P450 2C9 (CYP2C9) is crucial in excretion of commonly prescribed drugs. However, changes in metabolic activity caused by CYP2C9 polymorphisms inevitably result in adverse drug effects. <i>CYP2C9*2</i> and <i>*3</i> are prevalent in Caucasian populations whereas <i>CYP2C9*13</i> is remarkable in Asian populations. Single amino acid substitutions caused by these mutations are located outside catalytic cavity but affect kinetic activities of mutants compared to wild-type enzyme. To relate distal effects of these mutations and defective drug metabolisms, simulations of CYP2C9 binding to anti-coagulant (<i>S</i>)-warfarin were performed as a system model. Representative (<i>S</i>)-warfarin-bound forms of wild-type and mutants ...
Warfarin is the most commonly used drug for chronic prevention of thromboembolic events, it also ran...
Human cytochrome P450 2C9 (CYP2C9) accounts for ~20% of total hepatic CYP content and metabolizes ~1...
Item does not contain fulltextINTRODUCTION: Cytochrome P450 (CYP) plays a key role in the metabolism...
Cytochrome P450 2C9 (CYP2C9) is crucial in excretion of commonly prescribed drugs. However, changes ...
Cytochrome P450 2C9 (CYP2C9) metabolizes many clinically important drugs including warfarin and dicl...
Cytochrome P450 2C9 (CYP2C9) metabolizes about 15% of clinically administrated drugs. The allelic va...
International audienceCytochrome P450 2C9 (CYP2C9) metabolizes about 15% of clinically administrated...
CYP2C9 is the most abundant CYP2C subfamily enzyme in human liver and the most important contributor...
CYP2C9 metabolizes more than 100 clinically used drugs including phenytoin, S-warfarin, tolbutamide,...
There is a pronounced interindividual variability in the drug disposition, response and toxicity. P...
Warfarin (coumadin) is a worldwide-prescribed anticoagulant for the long-term treatment and preventi...
Objective: This study aimed to predict the effect of SNPs CYP2C9 s on the metabolic activity of S-wa...
Warfarin is the most frequently prescribed anticoagulant for the long-term treatment in the clinic. ...
Warfarin therapy is complicated by its large inter-individual and intra-individual variability. Both...
Human cytochrome P450 2C9 (CYP2C9) accounts for ~20% of hepatic total CYP content and metabolizes ~1...
Warfarin is the most commonly used drug for chronic prevention of thromboembolic events, it also ran...
Human cytochrome P450 2C9 (CYP2C9) accounts for ~20% of total hepatic CYP content and metabolizes ~1...
Item does not contain fulltextINTRODUCTION: Cytochrome P450 (CYP) plays a key role in the metabolism...
Cytochrome P450 2C9 (CYP2C9) is crucial in excretion of commonly prescribed drugs. However, changes ...
Cytochrome P450 2C9 (CYP2C9) metabolizes many clinically important drugs including warfarin and dicl...
Cytochrome P450 2C9 (CYP2C9) metabolizes about 15% of clinically administrated drugs. The allelic va...
International audienceCytochrome P450 2C9 (CYP2C9) metabolizes about 15% of clinically administrated...
CYP2C9 is the most abundant CYP2C subfamily enzyme in human liver and the most important contributor...
CYP2C9 metabolizes more than 100 clinically used drugs including phenytoin, S-warfarin, tolbutamide,...
There is a pronounced interindividual variability in the drug disposition, response and toxicity. P...
Warfarin (coumadin) is a worldwide-prescribed anticoagulant for the long-term treatment and preventi...
Objective: This study aimed to predict the effect of SNPs CYP2C9 s on the metabolic activity of S-wa...
Warfarin is the most frequently prescribed anticoagulant for the long-term treatment in the clinic. ...
Warfarin therapy is complicated by its large inter-individual and intra-individual variability. Both...
Human cytochrome P450 2C9 (CYP2C9) accounts for ~20% of hepatic total CYP content and metabolizes ~1...
Warfarin is the most commonly used drug for chronic prevention of thromboembolic events, it also ran...
Human cytochrome P450 2C9 (CYP2C9) accounts for ~20% of total hepatic CYP content and metabolizes ~1...
Item does not contain fulltextINTRODUCTION: Cytochrome P450 (CYP) plays a key role in the metabolism...