Inhibition of MMP activity by doxycycline.

<p>The BA was examined for gelatinolytic activity and MMP levels in ligated animals treated with or without doxycycline. (A) In situ zymography showing fluorescence of DQ-gelatin in the BA 5 days after carotid ligation. (B) Zymography of the BA 5 days after ligation in a rabbit treated with 20 mg/kg/day doxycycline. Scale bar = 50 microns. (C) Average intensity of unquenched fluorescence in the BA of ligated rabbits (n = 3 for each condition) with and without doxycycline (* indicates p<0.05). IU = intensity unit.