Comparison of trimeric gp140 versus monomeric gp120.

<p>(A) End-point binding titers of rabbits immunized with either trimeric gp140 (filled squares) or monomeric gp120 (open squares) of UG_A HIV-1 Env. Each dot represents one rabbit. Horizontal lines indicate mean titers. Statistical analysis was done using Mann-Whitney test. (B) Neutralization data using IgG (at a final concentration of 250 µg/ml) isolated from week 12 sera of rabbits immunized, in the presence of CAF01, with either trimeric gp140 or monomeric gp120 of UG_A. Neutralization of two clade B viruses, SF162 (left, squares) and Bx08 (right, diamonds) is depicted. Each dot represents one rabbit. Horizontal lines indicate the mean percent neutralization. Statistical analysis was done using Mann-Whitney test.