Appearance and progression of palpable mammary tumors are delayed in PyMT mice treated with AFS98.

<p>At 10 weeks of age, MMTV-PyMT mice were treated with 50 mg/kg of mAb AFS98, control rat IgG or PBS, injected IP 3 times per week from week 10 to week 13. <b>A</b>. The appearance of palpable tumors was delayed in AFS98-treated mice. The mean age (in weeks ± SEM) of palpable tumor detection is shown for each of the 3 mouse groups. * Mann-Whitney’s test p<0.05 compared with Rat IgG and PBS-treated mouse group (n = 10). <b>B</b>. Tumor volumes are shown as means ± SEM. * significant difference in tumor volume using Mann-Whitney’s test, p<0.05 between groups treated with Rat IgG and PBS (n = 15). <b>C</b>. Percentages of surviving mice in each group. * Log-rank test p<0.05 compared with the indicated mouse group (n = 10).