Functional annotation enrichment analysis of the 33-gene signature.

<p>Gene Ontology terms significantly over-represented in the 33-gene signature were identified and plotted using ClueGO. A) The size of the nodes are inversely proportional to the pvalue in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0074599#pone-0074599-g005" target="_blank">Fig. 5B</a>. Line widths between GO terms are proportional to the kappa scores used to define the categories. B) Table giving the results of the ClueGO analysis. Nr: Number of genes in our 33-gene signature associated with the GO term.%: Percentage of the genes of the considered GO term presents in our signature. Pvalue: pvalue of the GO term, corrected for multiple testing. C) Relation between the GO annotations of the 11 “cell adhesion”-associated genes in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0074599#pone-0074599-g005" target="_blank">Fig. 5B</a> and GO:0007155 term. Black arrows: “is a”. Green arrows: “Positively regulates”.