Effect of flavonoids on thyroid radioiodide uptake and effect of rutin on NIS.

<p>(A) Thyroid radioiodide uptake of rats treated with different flavonoids for five days (biochanin-A, catequin, fisetin, morin, naringenin, naringin, quercetin and rutin, 10mg/Kg body weight (BW), daily injections, sc.). Results are expressed as percentage of control group (n = 10 per group; *p < 0.05 vs. control); (B) Thyroid radioiodide uptake in rats treated with two different doses of rutin (10 or 20mg/Kg BW, daily injections, sc.) for five days. Results are expressed as percentage of control group (fold increase: rutin 10mg/Kg = 1.22; 20mg/Kg = 1.45; n = 15 per group; *p < 0.05 vs. control; **p < 0.01 vs. control); (C) Thyroid sodium-iodide symporter (NIS) protein levels in rats treated with 20mg/Kg BW rutin (daily injections, sc. for five days) (fold increase=1.34; n = 9 per group, *p < 0.05 vs. control); and (D) Thyroid NIS mRNA levels in rats treated with 20mg/Kg BW rutin (daily injections, sc. for five days) (fold increase=2.12; n = 10 per group, **p < 0.01 vs. control). GAPDH was used as internal control.