<div><p>The innate immune system of <i>Anopheles gambiae</i> mosquitoes limits <i>Plasmodium</i> infection through multiple molecular mechanisms. For example, midgut invasion by the parasite triggers an epithelial nitration response that promotes activation of the complement-like system. We found that suppression of the JNK pathway, by silencing either <i>Hep</i>, <i>JNK</i>, <i>Jun</i> or <i>Fos</i> expression, greatly enhanced <i>Plasmodium</i> infection; while overactivating this cascade, by silencing the suppressor <i>Puckered</i>, had the opposite effect. The JNK pathway limits infection via two coordinated responses. It induces the expression of two enzymes (HPx2 and NOX5) that potentiate midgut epithelial nitration in response to <i>...
Abstract Background Functional screens based on dsRNA-mediated gene silencing identified several Ano...
<div><p>Anopheline mosquitoes are the primary vectors of parasites in the genus <i>Plasmodium,</i> t...
Malaria transmission between humans depends on the ability of Anopheles mosquitoes to support Plasmo...
The innate immune system of Anopheles gambiae mosquitoes limits Plasmodium infection through multipl...
<p>(A) Basal mRNA expression of genes from the JNK pathway in the midgut and hemocytes of G3 suscept...
<p>(A) Diagram representing the organization of the JNK signaling cascade based on functional studie...
The Anopheles gambiae immune response against Plasmodium falciparum, an etiological agent of human m...
The mosquito Anopheles gambiae uses its innate immune system to control bacterial and Plasmodium inf...
<div><p>The <em>Anopheles gambiae</em> immune response against <em>Plasmodium falciparum</em>, an et...
Malaria is a global health concern caused by infection with Plasmodium parasites. With rising insect...
The mosquito Anopheles gambiae uses its innate immune system to control bacterial and Plasmodium inf...
Malaria affects 300 million people worldwide every year and 450,000 in Brazil. In coastal areas of B...
<div><h3>Background</h3><p>Mosquito-borne viral diseases cause significant burden in much of the dev...
Malaria is a global health concern caused by infection with Plasmodium parasites. With rising insect...
<div><p>The malarial parasite <em>Plasmodium</em> must complete a complex lifecycle in its <em>Anoph...
Abstract Background Functional screens based on dsRNA-mediated gene silencing identified several Ano...
<div><p>Anopheline mosquitoes are the primary vectors of parasites in the genus <i>Plasmodium,</i> t...
Malaria transmission between humans depends on the ability of Anopheles mosquitoes to support Plasmo...
The innate immune system of Anopheles gambiae mosquitoes limits Plasmodium infection through multipl...
<p>(A) Basal mRNA expression of genes from the JNK pathway in the midgut and hemocytes of G3 suscept...
<p>(A) Diagram representing the organization of the JNK signaling cascade based on functional studie...
The Anopheles gambiae immune response against Plasmodium falciparum, an etiological agent of human m...
The mosquito Anopheles gambiae uses its innate immune system to control bacterial and Plasmodium inf...
<div><p>The <em>Anopheles gambiae</em> immune response against <em>Plasmodium falciparum</em>, an et...
Malaria is a global health concern caused by infection with Plasmodium parasites. With rising insect...
The mosquito Anopheles gambiae uses its innate immune system to control bacterial and Plasmodium inf...
Malaria affects 300 million people worldwide every year and 450,000 in Brazil. In coastal areas of B...
<div><h3>Background</h3><p>Mosquito-borne viral diseases cause significant burden in much of the dev...
Malaria is a global health concern caused by infection with Plasmodium parasites. With rising insect...
<div><p>The malarial parasite <em>Plasmodium</em> must complete a complex lifecycle in its <em>Anoph...
Abstract Background Functional screens based on dsRNA-mediated gene silencing identified several Ano...
<div><p>Anopheline mosquitoes are the primary vectors of parasites in the genus <i>Plasmodium,</i> t...
Malaria transmission between humans depends on the ability of Anopheles mosquitoes to support Plasmo...