Dependence of mutational load on ploidy and mutant selection.

<p><b>A.</b> Number of mutations for different types of HAP-treated genomes. <b>B.</b> Number of mutations for different types of PmCDA1-treated genomes. Bars are median values. Note the logarithmic scale. <i>p</i> values for Mann-Whitney test are shown for significant differences. <b>C.</b> Viability of haploid spores obtained from different diploid clones. Spores resulting from dissecting tetrads produced from wild-type strains (LAN211 and LAN210), mutants induced by HAP (LAN211-5) and PmCDA1 (LAN210-L4), and non-mutant clones treated with HAP (LAN211-NM3) and PmCDA1 (LAN210-NM2) are shown. Each vertical row of four colonies represents the progeny of four haploid spores produced in a single meiosis.