<p>Hippocampal cGMP levels were analyzed in wild-type (WT) and R6/1 mice at 8 and 12 weeks of age by enzyme immunoassay. Values are expressed as percentage of WT mice, and are the mean ± SEM (n=7-10). Data were analyzed by Student’s t-test. ***<i>p</i><0.001 as compared with age-matched WT mice.</p
<p>(A) Representative KDEL (green) immunostaining for wt and 14-3-3ζtg mice hippocampus. Neurons are...
<p>Hippocampi were isolated from the brains of C57BL/6J mice at 3–6 months (young, Yg), 12 months (m...
<p>Results are expressed as mean ± standard deviation for five independent experiments (animals) per...
<p>cGMP levels were measured in six week-old mice, before the onset of degeneration as evidenced by ...
<p>nNOS (A), PDE5A (B) and PDE9A (C) protein levels were analyzed by Western blot of protein extract...
<div><p>Western blot analysis of DRMs prepared from equal amounts of hippocampal extracts (100 µg of...
<div><p>Western blot analysis of equal amounts of protein from hippocampal membrane extracts (25 µg ...
*<p><i>P</i><0.05;</p>**<p><i>P</i><0.01;</p>***<p><i>P</i><0.001;</p><p>Pooled data from 9–18 month...
<p>All GC species in WT mice showed age-dependent decrease with age (from <1 d, 6–9 wks to 52 wks) i...
<p><b>A and B</b>, Comparison of GFAP staining in SR from sedentary and exercised mice. Image analys...
<p>(<b>A</b>) Transcript levels of Gfap-α in cortex of APPswePS1dE9 mice increase with age (months)....
<p>(A) Brain homogenates, (E) hippocampal and (I) spinal cord homogenates from ntg, TAR6 and TAR6/6 ...
<p>(A) Quantitative PCR analysis using mRNA isolated from dissected striatum in unmanipulated YAC128...
<p>Enzyme activities of SMO, APAO, ODC and SSAT and PA content from cortex and cerebellum of 3 (3 m)...
<p>Results are expressed as mean ± standard deviation for five independent experiments (animals) per...
<p>(A) Representative KDEL (green) immunostaining for wt and 14-3-3ζtg mice hippocampus. Neurons are...
<p>Hippocampi were isolated from the brains of C57BL/6J mice at 3–6 months (young, Yg), 12 months (m...
<p>Results are expressed as mean ± standard deviation for five independent experiments (animals) per...
<p>cGMP levels were measured in six week-old mice, before the onset of degeneration as evidenced by ...
<p>nNOS (A), PDE5A (B) and PDE9A (C) protein levels were analyzed by Western blot of protein extract...
<div><p>Western blot analysis of DRMs prepared from equal amounts of hippocampal extracts (100 µg of...
<div><p>Western blot analysis of equal amounts of protein from hippocampal membrane extracts (25 µg ...
*<p><i>P</i><0.05;</p>**<p><i>P</i><0.01;</p>***<p><i>P</i><0.001;</p><p>Pooled data from 9–18 month...
<p>All GC species in WT mice showed age-dependent decrease with age (from <1 d, 6–9 wks to 52 wks) i...
<p><b>A and B</b>, Comparison of GFAP staining in SR from sedentary and exercised mice. Image analys...
<p>(<b>A</b>) Transcript levels of Gfap-α in cortex of APPswePS1dE9 mice increase with age (months)....
<p>(A) Brain homogenates, (E) hippocampal and (I) spinal cord homogenates from ntg, TAR6 and TAR6/6 ...
<p>(A) Quantitative PCR analysis using mRNA isolated from dissected striatum in unmanipulated YAC128...
<p>Enzyme activities of SMO, APAO, ODC and SSAT and PA content from cortex and cerebellum of 3 (3 m)...
<p>Results are expressed as mean ± standard deviation for five independent experiments (animals) per...
<p>(A) Representative KDEL (green) immunostaining for wt and 14-3-3ζtg mice hippocampus. Neurons are...
<p>Hippocampi were isolated from the brains of C57BL/6J mice at 3–6 months (young, Yg), 12 months (m...
<p>Results are expressed as mean ± standard deviation for five independent experiments (animals) per...