Facile One-Pot Assembly of Imidazotriazolobenzodiazepines via Indium(III)-Catalyzed Multicomponent Reactions

An operationally simple, one-pot multicomponent reaction has been developed for the assembly of 9<i>H</i>-benzo[<i>f</i>]imidazo[1,2-<i>d</i>][1,2,3]triazolo[1,5-<i>a</i>][1,4]diazepines adorned with three diversification points via an atom-economical transformation incorporating α-diketones, <i>o</i>-azidobenzaldehydes, propargylic amines, and ammonium acetate. This process involves tandem InCl₃-catalyzed cyclocondensation and intramolecular azide–alkyne 1,3-dipolar cycloaddition reactions; optimization data, substrate scope, and mechanistic insights are discussed