TQ inhibits glioblastoma cell proliferation.

<p>A) T98G, U87MG and Gli36ΔEGFR cells were incubated with increasing concentrations of TQ for 7–10 days. At the end of the growth period colonies were fixed, stained and counted. After taking into account the plating efficiency for each cell line, the surviving fraction is the ratio of the number of colonies counted and the initial number of cells plated. Mean ± S.D., n = 3. B) The effect of TQ on proliferation of normal human astrocytes (NHAs) compared to Gli36ΔEGFR cells was determined by a modified clonogenic assay. Cells were plated at a low density and incubated with increasing concentrations of TQ for 5 days. At the end of the growth period, cells were fixed, stained and photographed for estimation of proliferation relative to untreated cells.