<p>Correlation plots between the measured outputs and predicted outputs with NGF (<b>A</b>), PACAP (<b>B</b>) and anisomycin (<b>C</b>). The correlation coefficient, <i>r</i>, is indicated in each plot. Each dot represents a single time point. The data sets with PD0325901 (MEK inhibitor), H89 (PKA inhibitor), LY294002 (PI3K inhibitor), SB203580 (p38 inhibitor), SP600125 (JNK inhibitor) (<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0072780#pone.0072780.s004" target="_blank">Table S2</a>) are indicated by the various colors.</p
<p>(A) PCA scores plot for the N and K groups for rat serum. The red dot is the control group (N), a...
<p>(A) Plot of predicted QTc vs. actual (measured) QTc from the PLS model using the cross-validation...
<p>(a) All-FabD, (b) TgFabD, (c) PfFabD based on dG, ElecStat, VDW Y-response variables, respectivel...
<p>Correlation plots between the measured outputs and predicted outputs using same experiment as <a ...
<p>(<b>A</b>) Construction of the PLS model. Inputs matrix <b>X</b> (20×60) regressed against the ou...
a<p>A high ratio between Q<sup>2</sup> and R<sup>2</sup> confirms the validity of the models.</p>b<p...
<p>A) Heatmaps showing model simulations of the impact of 50% inhibitor I individually or in combina...
Validation of TIDES via short-term drug inhibition. (A) (I) 3D-DREVI plot shows a typical behavior o...
<p>Correlation plot between Hypo1 predicted Btk inhibitory activities and experimental activities of...
<p>Dilution series of the MEK inhibitor AZD-6244 (rows, in nM) and the PI3K inhibitor GDC-0941 (colu...
The relationship between the KIPA-based PBP signature score, immune scores, and immune checkpoint le...
<p>Qualitative analysis of networks from <i>in silico</i> simulations nominates PLK1 and Cyclin B1 a...
<p><b>5A</b> Range of correlation values at each coverage level for the pair-wise comparisons of the...
<p>(A) The time series of pMAPKs and pCREB in response to NGF (5 ng/ml, red), PACAP (100 nM, blue), ...
<p>(A) PCA score plot (t<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.006055...
<p>(A) PCA scores plot for the N and K groups for rat serum. The red dot is the control group (N), a...
<p>(A) Plot of predicted QTc vs. actual (measured) QTc from the PLS model using the cross-validation...
<p>(a) All-FabD, (b) TgFabD, (c) PfFabD based on dG, ElecStat, VDW Y-response variables, respectivel...
<p>Correlation plots between the measured outputs and predicted outputs using same experiment as <a ...
<p>(<b>A</b>) Construction of the PLS model. Inputs matrix <b>X</b> (20×60) regressed against the ou...
a<p>A high ratio between Q<sup>2</sup> and R<sup>2</sup> confirms the validity of the models.</p>b<p...
<p>A) Heatmaps showing model simulations of the impact of 50% inhibitor I individually or in combina...
Validation of TIDES via short-term drug inhibition. (A) (I) 3D-DREVI plot shows a typical behavior o...
<p>Correlation plot between Hypo1 predicted Btk inhibitory activities and experimental activities of...
<p>Dilution series of the MEK inhibitor AZD-6244 (rows, in nM) and the PI3K inhibitor GDC-0941 (colu...
The relationship between the KIPA-based PBP signature score, immune scores, and immune checkpoint le...
<p>Qualitative analysis of networks from <i>in silico</i> simulations nominates PLK1 and Cyclin B1 a...
<p><b>5A</b> Range of correlation values at each coverage level for the pair-wise comparisons of the...
<p>(A) The time series of pMAPKs and pCREB in response to NGF (5 ng/ml, red), PACAP (100 nM, blue), ...
<p>(A) PCA score plot (t<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.006055...
<p>(A) PCA scores plot for the N and K groups for rat serum. The red dot is the control group (N), a...
<p>(A) Plot of predicted QTc vs. actual (measured) QTc from the PLS model using the cross-validation...
<p>(a) All-FabD, (b) TgFabD, (c) PfFabD based on dG, ElecStat, VDW Y-response variables, respectivel...