Effect of Arg on DTT-induced aggregation of BSA ([BSA] = 1.0 mg/ml, 2 mM DTT).

<p>(A) The dependences of the light scattering intensity on time obtained at the following concentrations of Arg: (1) 0, (2) 50 and (3) 400 mM. Points are the experimental data. The solid curves was calculated from Eq. (5). (B) The dependences of the hydrodynamic radius (<i>R</i>_h) of the protein aggregates on time obtained in the absence of Arg (1) and in the presence of 400 mM Arg (2). (C) The dependence of the <i>K</i>_agg/<i>K</i>_agg,0 ratio on the concentration of Arg. Points are the experimental data. The solid curve was calculated from Eq. (20). Inset shows the dependence of the duration of the lag period (<i>t</i>₀) on the concentration of Arg.