Distribution profiles of CL and Gal-lipo in the liver of mouse.

<p>The conventional liposomes (CL) and galactosylated liposomes (Gal-lipo) were labeled by DiR. Each liposome containing a total of 200 µg of lipid was ininjected into Balb/c-nu mice via either tail intravenous or spleen administration. The <i>in vivo</i> biodistribution was monitored by a live animal imaging system with Ex/Em of 745 nm/820 nm at various time point post injection. The photon radiance on the surface of the liver of an animal was expressed as photons per second per square centimeter per steradian (p/sec/cm²/sr). Images are compound pictures generated by Living Image software. A) In vivo longitudinal monitoring of both liposomes. B) The analysis of fluorescence imaging using Living Image software.