Analysis of murinized H7858 <i>L. monocytogenes</i>.

<p>(A) The murinized H7858 strain has a greater ability to infect the mouse by the oral route compared to the wild-type strain. BALB/c mice were orally infected with 1 x 10¹⁰ CFU with either the murinized and wild-type H7858 strain. Bacterial CFU in the liver (black bars) and spleen (grey bars) were enumerated at 3 days post-infection. N=5 mice per group and the values are the mean and standard deviation. (B) Invasion assay of Caco₂ cell line by wild-type and murinized H7858. Under our conditions tested the murinized strain had a decreased ability to invade the Caco₂ cell line. This was carried out in triplicate and the values are the mean and standard deviation. * indicates P<0.05 relative to control strain.