<i>In vivo</i> pulmonary metastatic treatment experiments in mice vaccinated with various protein vaccines.

<p>(<b>A</b>) Representative figures of pulmonary tumor nodules in the treatment experiments of each protein vaccinated group. (<b>B</b>) The mean pulmonary tumor nodules in the mice vaccinated with various protein vaccines 3 days after TC-1 tumor injection. <i>Note</i>: The mean number of nodules in the mice treated with PE(ΔIII)/E6 (30.6±4.1), PE(ΔIII)/E7 (1.2±0.6), and PE(ΔIII)/E6+PE(ΔIII)/E7 (0.8±0.4) fusion proteins were significantly lower than in the other groups of mice (<i>p</i><0.001, one-way ANOVA). (<b>C</b>) The mean pulmonary tumor nodules of the mice treated with various protein vaccines 7 days after TC-1 tumor injection. <i>Note</i>: The PE(ΔIII)/E6+PE(ΔIII)/E7 group (10.8±2.5) had the lowest number of pulmonary tumor nodules compared to the PE(ΔIII)/E6 (60.4±10.6) and PE(ΔIII)/E7 (20.8±3.6) groups (<i>p</i><0.01, one-way ANOVA).