Distribution of gray matter volume and ‘disinhibition’ scores for brain areas showing a significant interaction between gender and genotype.

<p>Gray matter volume (GMV) in right amygdala (upper row), left orbitofrontal cortex (second row), left dorsolateral prefrontal cortex (third row) and right prefrontal cortex (bottom row) plotted against values on the ‘disinhibition’ subscale of the Three Factor Eating Questionnaire (TFEQ 51) for women (middle column) and men (right column) separately. Left column indicates the brain region where gray matter volume was extracted. Filled dark circles indicate homozygous carriers of the risk allele (CC) at rs17782313, filled gray circles indicate heterozygous subjects (AC) and open circles indicate homozygous carriers of the wildtype allele (AA). pr = partial correlation coefficient controlling for BMI, p = p-value of partial correlation analysis.