BMP7 decreases obesity and attenuates liver lipid accumulation, dyslipidemia and hyperglycemia in diet-induced obese mice.

<p>8-week-old male C57Bl/6J mice were fed a high-fat diet (45% fat) for 12 weeks and then treated for 4 weeks with BMP7 (100 µg/kg/day) or saline via a subcutaneous osmotic minipump at an environmental temperature of 21°C while feeding a high-fat diet <i>(A)</i> Body weight development (gram) <i>(B)</i> Total fat mass as measured via DEXA-scan (expressed as percentage of body weight) <i>(C)</i> Energy expenditure measured during 5 consecutive days in the fourth week of treatment via fully automatic metabolic cages <i>(D)</i> Liver content of triglycerides (TG), total cholesterol (TC) and phospholipids (PL) <i>(E)</i> Plasma triglyceride (TG) and total cholesterol (TC) levels. <i>(F)</i> Plasma glucose levels. Values are means<u>+</u>SEM (n = 9). *P<0.05, **P<0.01 compared to the control group.