Homology Modeling of <i>Homo sapiens</i> IKKβ.

<p>(A) Domain structure of IKKβ. IKKβ can be divided into three function domains: a kinase domain (KD), an ubiquitin-like domain (ULD) and an elongated, α-helical scaffold/dimerization domain (SDD) colored as green, red and yellow. (B) Ribbon diagram of <i>Homo sapiens</i> IKKβ from Homology Modeling. KD (green), ULD (red) and SDD (yellow) are labeled. (C) Superimpose of <i>Homo sapiens</i> IKKβ and <i>Xenopus laevis</i> IKKβ. The Keap1 binding motif is colored as azure. In general, the structure of <i>Homo sapiens</i> IKKβ (yellow) and <i>Xenopus laevis</i> IKKβ (red) are quite similar. Both of the Keap1 binding motifs (blue) form the β-turn structure. (D) & (E) Structure difference of Keap1 binding motif between <i>Homo sapiens</i> IKKβ (red) and <i>Xenopus laevis</i> IKKβ (blue). The most different residues were labeled in the picture.