Effects of sinomenine on body weight, survival rate and diarrhea score in TNBS-induced colitis in mice. A. Efficacy of sinomenine on body weight.

<p>Body weight increased during administration of different doses (100 and 200 mg/kg) of sinomenine over 7 days. <b>B. Improvement of survival rate in TNBS-induced colitis by sinomenine.</b> TNBS-induced colitis resulted in animal death over the course of the whole experiment when compared with the vehicle group, however the sinomenine group showed a much lower mortality rate. <b>C. Effect on diarrhea signs of colonic inflammation by sinomenine.</b> TNBS-induced colitis showed serious diarrhea symptoms until day 6, but administration of sinomenine significantly reduced the diarrhea score over the course of the experiment. n = 15 per group, *<i>p</i><0.05 versus the vehicle group and ^#<i>p</i><0.05 versus the TNBS group.