Lung metastasis in the spontaneous metastasis model.

<p>Eight days after leg resection, mice were sacrificed, and lung metastasis was evaluated. A: Gross appearance. B: Hematoxylin and eosin (H&E) staining. Arrowheads indicate metastasis. Bar = 1 mm. C: Weight of lungs from WT and <i>VASH1 (−/−)</i> mice is shown (N = 7). *p<0.05. D: Number of metastatic nodules in the lungs of WT and <i>VASH1 (−/−)</i> mice is given (N = 7). **p<0.01.