Stat3 is involved in the MIF-Sox6 signaling cascade in NSPCs.

<p>(A) Retrovirally-over expressed constitutively active Stat3 (pMX-Stat3-C) increased the gene expression levels of <i>Sox6, Hes1,</i> and <i>Hes3</i> in NSPCs compared to the expression levels in control retrovirus (pMX)-infected NSPCs 4 days after infection. Data are average of two independent experiments. (B) Changes in the binding ability of Stat3 to the <i>Sox6</i> promoter following MIF treatment (400 ng/ml, 5 days) in NSPCs were analyzed using the ChIP qPCR technique. Error bars indicate S.D. values; *<i>P</i><0.05; Student’s <i>t</i>-test. Data are derived from three independent experiments.