APP is needed to induce EGR-1 by novelty.

<p><b>A</b>) EGR-1mRNA levels were quantified by q-RT PCR in cortex of APP+/+ and APP-/- mouse exposed (OF) or not (not stimulated: NS) to the open field during 15 min (n=10). Values were normalized to the GAPDH mRNA, and expressed as percentage of the APP+/+ NS. One way Anova (***p<0.001) <b>B</b>) Chromatin immunoprecipitations of EGR-1 promoter were performed on chromatin isolated from cerebral cortex APP +/+ and APP -/- mice exposed or not to novelty (n=7 per group) with normal IgG as negative control and anti-acetylated H4 antibody. Immunoprecipitated DNA was quantified by qPCR and normalized to the input. Two way Anova, *p<0.05.