Non-brain metastatic cells uptake exosomes from their derivatives brain metastatic (BM) cell lines.

<p>Exosomes from the BM cell lines were labeled with green lipophilic fluorescent dye PKH67 and incubated for 5-BM cells transduced with Tubulin-RFP and visualized by fluorescence microscopy. (<b>A</b>) MDA-MB-231P (231P) cells with MDA-MB-231BR-derived exosomes. (<b>B</b>) CTC1P cells with CTC1BMSM-derived exosomes. (<b>C</b>) MeWo cells with 70 W-derived exosomes. Numerous green fluorescent labeled exosomes were observed inside the cells, mostly located at the perinuclear region.