Occurrence and Potential Causes of Androgenic Activities in Source and Drinking Water in China
- Xinxin Hu (429652)
- Wei Shi (68167)
- Si Wei (476944)
- Xiaowei Zhang (6505)
- Jianfang Feng (1586380)
- Guanjiu Hu (1911361)
- Sulan Chen (1911364)
- John P. Giesy (302766)
- Hongxia Yu (1461871)
DOIAbstract
The increased incidences of disorders of male reproductive tract as well as testicular and prostate cancers have been attributed to androgenic pollutants in the environment. Drinking water is one pathway of exposure through which humans can be exposed. In this study, both potencies of androgen receptor (AR) agonists and antagonists were determined in organic extracts of raw source water as well as finished water from waterworks, tap water, boiled water, and poured boiled water in eastern China. Ten of 13 samples of source water exhibited detectable AR antagonistic potencies with AR antagonist equivalents (Ant-AR-EQs) ranging from <15.3 (detection limit) to 140 μg flutamide/L. However, no AR agonistic activity was detected in any source wate...
Add to ORKG