Knock-down of CD44 inhibits proliferation of bladder carcinoma cells <i>in vitro</i>.

<p>(<b>A</b>) representative bright field images of J82 cells 4 days after knock-down of RHAMM, CD44 and RHAMM plus CD44 plusminus 100 µg HA/ml (Healon 5) in 10% FCS. (<b>B</b>) proliferation of J82 cells after knock-down of RHAMM, CD44 and CD44 plus RHAMM in J82 cells 4 days after transfection plusminus exogenous HA (100 µg/ml). (<b>C</b>) analysis of apoptosis was performed 4 days after transfection with siRNA as in A and B by immunoblotting of PARP and cleaved PARP. (<b>D</b>) PARP cleavage was quantified as the ratio of cleaved and uncleaved PARP; mean ± SEM, *, p<0.05.