<div><p>Background</p><p>Endocrine treatment is the most preferable systemic treatment in metastatic breast cancer patients that have had an estrogen receptor (ER) positive primary tumor or metastatic lesions, however, approximately 20% of these patients do not benefit from the therapy and demonstrate further metastatic progress. One reason for failure of endocrine therapy might be the heterogeneity of ER expression in tumor cells spreading from the primary tumor to distant sites which is reflected in detectable circulating tumor cells (CTCs).</p><p>Methods</p><p>A sensitive and specific staining protocol for ER, keratin 8/18/19, CD45 was established. Peripheral blood from 35 metastatic breast cancer patients with ER-positive primary tumors...
Purpose: Early detection is essential for treatment plans before onset of metastatic disease. Our pu...
Abstract Circulating tumor cells (CTC) are prognostic in metastatic breast cancer (MBC). The CTC-end...
BACKGROUND: Preclinical and clinical studies have reported that human epidermal growth factor recept...
Endocrine treatment is the most preferable systemic treatment in metastatic breast cancer patients t...
Endocrine treatment is the most preferable systemic treatment in metastatic breast cancer patients t...
Background: The estrogen receptor (ER) can change expression between primary tumor (PT) and distant ...
Androgen receptor (AR) is frequently detected in breast cancers, and AR-targeted therapies are showi...
AbstractHormone therapy and anti-ErbB2 therapies are prescribed according to the hormone receptor [e...
Purpose: Early detection is essential for treatment plans before onset of metastatic disease. Our pu...
Purpose: Early detection is essential for treatment plans before onset of metastatic disease. Our pu...
Purpose: Early detection is essential for treatment plans before onset of metastatic disease. Our pu...
Purpose: Early detection is essential for treatment plans before onset of metastatic disease. Our pu...
PURPOSE: Common resistance mechanisms to endocrine therapy (ET) in estrogen receptor (ER)-positive m...
Mutations and splice variants in the estrogen receptor (ER) gene, ESR1, may yield endocrine resistan...
Purpose: Early detection is essential for treatment plans before onset of metastatic disease. Our pu...
Purpose: Early detection is essential for treatment plans before onset of metastatic disease. Our pu...
Abstract Circulating tumor cells (CTC) are prognostic in metastatic breast cancer (MBC). The CTC-end...
BACKGROUND: Preclinical and clinical studies have reported that human epidermal growth factor recept...
Endocrine treatment is the most preferable systemic treatment in metastatic breast cancer patients t...
Endocrine treatment is the most preferable systemic treatment in metastatic breast cancer patients t...
Background: The estrogen receptor (ER) can change expression between primary tumor (PT) and distant ...
Androgen receptor (AR) is frequently detected in breast cancers, and AR-targeted therapies are showi...
AbstractHormone therapy and anti-ErbB2 therapies are prescribed according to the hormone receptor [e...
Purpose: Early detection is essential for treatment plans before onset of metastatic disease. Our pu...
Purpose: Early detection is essential for treatment plans before onset of metastatic disease. Our pu...
Purpose: Early detection is essential for treatment plans before onset of metastatic disease. Our pu...
Purpose: Early detection is essential for treatment plans before onset of metastatic disease. Our pu...
PURPOSE: Common resistance mechanisms to endocrine therapy (ET) in estrogen receptor (ER)-positive m...
Mutations and splice variants in the estrogen receptor (ER) gene, ESR1, may yield endocrine resistan...
Purpose: Early detection is essential for treatment plans before onset of metastatic disease. Our pu...
Purpose: Early detection is essential for treatment plans before onset of metastatic disease. Our pu...
Abstract Circulating tumor cells (CTC) are prognostic in metastatic breast cancer (MBC). The CTC-end...
BACKGROUND: Preclinical and clinical studies have reported that human epidermal growth factor recept...