<p>(A) Immunohistochemical analysis of the effects of suppressing <i>CCL2</i>, <i>CCL7</i> or <i>CCL8</i> in tumor-supportive fibroblasts on cancer cell proliferation, immune cell recruitment, blood vessel recruitment and mesenchymal cell activation in Cal51 tumors, using antibodies to Ki-67 (proliferation), antigen #7/4 (immune cells; neutrophils and monocytes), CD31 (endothelial cells of blood vessels) and α-SMA (mesenchymal cell activation). Scale bars represent 50 µm for Ki-67, antigen #7/4 and CD31 panels and 100 µm for α-SMA. (B–E) Quantification of tumor cell proliferation, monocytes and neutrophils, blood vessel endothelial cells, and mesenchymal cell activation. For each property, five different fields of three different tumors per...
Current advances in cancer immunotherapy are hindered by the immunosuppressive nature of the tumor m...
Many fibroblast-secreted proteins promote tumorigenicity, and several factors secreted by cancer cel...
[[abstract]]Certain immune cells and inflammatory cytokines are essential components in the tumor mi...
<p>(A) Tumor-supportive fibroblasts HFFF2 increase Cal51 tumor cell proliferation and increase strom...
<p>(A) Reduction of CCL2 protein in HFFF2 fibroblasts by expressing shRNAs targeting <i>CCL2</i> as ...
<p>Summary of results obtained from tumorigenicity assays and immunohistochemical characterization o...
<p>(A) Paracrine upregulation of the expression of ligand-receptor pairs upon co-culture of tumor su...
CCL2, a chemokine also referred to as monocyte chemoattractant protein 1 (MCP-1) and small inducible...
Stromal cell-secreted chemokines including CCL2 have been implicated in the primary tumor microenvir...
The tumor microenvironment consists of stromal cells and leukocytes that contribute to cancer progre...
PURPOSE: Chemokines are involved in cancer-related inflammation and malignant progression. In this s...
<p>(<b>A</b> and <b>B</b>) Proportions of monocytes in the spleen (<b>A</b>) and bone marrow (<b>B</...
Recent studies have shown that stromal fibroblasts have a more profound influence on the initiation ...
Stromal cell-secreted chemokines including CCL2 have been implicated in the primary tumor microenvir...
Chemokines mediate the inflammatory response by attracting various leukocyte types. MCP-2/CC chemoki...
Current advances in cancer immunotherapy are hindered by the immunosuppressive nature of the tumor m...
Many fibroblast-secreted proteins promote tumorigenicity, and several factors secreted by cancer cel...
[[abstract]]Certain immune cells and inflammatory cytokines are essential components in the tumor mi...
<p>(A) Tumor-supportive fibroblasts HFFF2 increase Cal51 tumor cell proliferation and increase strom...
<p>(A) Reduction of CCL2 protein in HFFF2 fibroblasts by expressing shRNAs targeting <i>CCL2</i> as ...
<p>Summary of results obtained from tumorigenicity assays and immunohistochemical characterization o...
<p>(A) Paracrine upregulation of the expression of ligand-receptor pairs upon co-culture of tumor su...
CCL2, a chemokine also referred to as monocyte chemoattractant protein 1 (MCP-1) and small inducible...
Stromal cell-secreted chemokines including CCL2 have been implicated in the primary tumor microenvir...
The tumor microenvironment consists of stromal cells and leukocytes that contribute to cancer progre...
PURPOSE: Chemokines are involved in cancer-related inflammation and malignant progression. In this s...
<p>(<b>A</b> and <b>B</b>) Proportions of monocytes in the spleen (<b>A</b>) and bone marrow (<b>B</...
Recent studies have shown that stromal fibroblasts have a more profound influence on the initiation ...
Stromal cell-secreted chemokines including CCL2 have been implicated in the primary tumor microenvir...
Chemokines mediate the inflammatory response by attracting various leukocyte types. MCP-2/CC chemoki...
Current advances in cancer immunotherapy are hindered by the immunosuppressive nature of the tumor m...
Many fibroblast-secreted proteins promote tumorigenicity, and several factors secreted by cancer cel...
[[abstract]]Certain immune cells and inflammatory cytokines are essential components in the tumor mi...