Deletion of <i>miR-1/133a</i> clusters induces up-regulation of smooth muscle-specific genes leading to multiple transcriptional changes in embryonic hearts.
- Katharina Wystub (460622)
- Johannes Besser (460623)
- Angela Bachmann (460624)
- Thomas Boettger (372827)
- Thomas Braun (269597)
Publication date
September 2013
DOIAbstract
<p>(A) DNA microarray-based transcriptional analysis of <i>miR-1/133a</i> dKO mutant hearts at E10.5. Genes associated with heart development showing significant (red: p-values) expression changes are shown (up-regulated genes: red, down-regulated genes: green). Putative miR-1/133a target genes are indicated. (B–F) qRT-PCR analysis (Taqman) of increased expression of ANP, myocardin, smooth muscle actin, transgelin, myh11 and BMP-10 in <i>miR-1/133a</i> dKO hearts.</p
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