Transcriptional down-regulation precedes the gain of repressive H3K27me3 chromatin marks.

<p>ChIP analysis of ΔE3A-LCL^doxE3A cells showing the abundance of (A) Pol II, (B) H3ac, (C) H3K4me3, and (D) H3K27me3 across the <i>CXCL10</i> locus (primer pairs H-J, see <a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1003638#ppat-1003638-g003" target="_blank">Figure 3A</a>) prior to and 24 h post EBNA3A induction with 100 ng/ml Dox. Primer pair S was used as a control. Bars were calculated and displayed as in <a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1003638#ppat-1003638-g003" target="_blank">Figure 3</a>. ChIP analyses of a wt LCL were included for comparison.