Effect of synaptic blockers on ON-type ganglion cell spontaneous activity.

<p>The cocktail of blockers contained (in μM): 50 L-AP4, 10 bicuculline, 10 strychnine, 50 D-AP5, and 10 CNQX. A. Representative traces show that spontaneous activity was completely eliminated in a control ON-type ganglion cell (upper panel) and a diabetic ON-type ganglion cell (middle panel), but was maintained to some extent in another diabetic ON-type ganglion cell (lower panel). Summarized data show that spontaneous firing rate of each ON-type cell was recorded before and after application of the synaptic blockers in control (B) and diabetic retinas (C). Grey circles show firing rate of each cell.