Endoret treatment modulates neurogenesis in APP/PS1 mice.

<p>A. Representative fields of BrdU immunostaining in the hippocampal dentate gyrus (DG) of 3 (upper) and 6 months of age (bottom) APP/PS1 mice treated with vehicle or Endoret. Scale bar = 20µm. B. Quantification of BrdU-positive cells after vehicle or Endoret intranasal administration in 3 and 6 month-old APP/PS1 mice. C. Representative confocal microscopy images DG of brain sections immunostained for DCX (red) in combination with NeuN (green) shown in 3 (upper) and 6-month old (bottom) APP/PS1 mice treated with vehicle or Endoret. Scale bar = 20µm. D. Quantification of neurogenesis in 3 and 6 month-old APP/PS1 mice. E. Representative confocal microscopy images DG of brain sections immunostained for BrdU (green) and NeuN (red) in 6 month-old APP/PS1 mice. Arrows point to merged signals. Scale bar = 20µm. F. Quantification of the relative number of BrdU and NeuN double positive cells. n = 9 mice per group. Data show mean ± SEM; **p<0.01 vs APP/PS1 + vehicle.