Resveratrol inhibited T cell activation in vitro and in vivo.

<p>(<b>a</b>) The proliferation of CD4⁺ T cells treated with different concentrations of resveratrol was evaluated by CFSE labeling assay. (<b>b</b>) The proliferation of CD4⁺ T cells treated with different concentrations of resveratrol was measured by BrdU proliferation assay. (<b>c</b>–<b>f</b>) The productions of cytokines in supernatant of cell cultures, including IL-2 (<b>c</b>), IFNγ (<b>d</b>), IL-4 (<b>e</b>) and IL-5 (<b>f</b>), were measured by ELISA (*<i>P</i> < 0.05, **<i>P</i> < 0.01, ***<i>P</i> < 0.001). The data are representative of at least five independent experiments.