NADPH oxidase is involved in the 6-OHDA-mediated degeneration of DA neurons in SN.

<p>A, apomorphine-induced contralateral rotations evaluated at 14 days post-PD induction in Sham, Wt 6-OHDA-lesioned mice and gp91^phox-/- 6-OHDA lesioned mice groups; n=12. Values are expressed as percent of induced rotations/min in relation to the Sham group. Representative digital images demonstrating TH-immunoreactive cell bodies in the SN of Wt saline, Wt 6-OHDA and gp91^phox-/- 6-OHDA-lesioned mice groups (B). Images are representative of at least six independent experiments. The statistical significance is expressed as: *** P<0.001 <i>versus</i> Wt Sham group and *** p<0.001 gp91^phox-/- 6-OHDA <i>versus</i> Wt 6-OHDA.