The coiled-coil of ATG16L1 is highly conserved across vertebrates.

<p>(A) Cross-species alignment of the coiled-coil (human residues M126 – A207) of ATG16L1 reveals levels of sequence identity with the human sequence of between 73% and 100%. The percentage identity listed is in comparison with the human sequence. The common names and database identifies for each sequence are listed in Materials and Methods. (B) The syntenic position of <i>Atg16L1</i> is well conserved across species. The three adjacent upstream and downstream genese to <i>Atg16L1</i> are displayed. Genes are denoted by individual blocks; yellow indicates a position on the forward strand and green a position on the reverse strand. Gene identities are as follows: ATG16L1 – autophagy related protein 16 isoform 1; SAG – S-antigen, retina and pineal gland; DGKD – diacylglycerol kinase delta; USP40 – ubiquitin specific peptidase 40; INPP5D – inositol polyphosphate-5-phosphatase; NEU2 – sialidase 2; NGEF - neuronal guanine exchange factor; TRPV2 – transient receptor potential cation channel, subfamily V, member 2; UBB – ubiquitin B; AC106876.2 – uncharacterised; 00570 (ENSMODG00000000570) – uncharacterised; 23152 (ENSMODG00000023152) – uncharacterised, BLASTp indicates a possible ortholog of glyceraldehydes 3-phosphate dehydrogenase.