Leucine supplementation in HF-fed mice improves insulin sensitivity.

<p>(<b>A</b>) Glucose tolerance test and (<b>B</b>) insulin tolerance test carried out in HFD- or chow-fed mice supplemented or not with leucine in drinking water (n = 10-11 per group). (<b>C</b>) Fasting plasma glucose, (<b>D</b>) fasting plasma insulin and (<b>E</b>) HOMA index measured in mice on HFD supplemented or not with leucine in drinking water (n = 10-11 per group). ^*<i>p</i><0.05 vs. HFD-water group; ^#<i>p</i><0.05 vs. chow-fed groups.