Immunological intervention with MRPs controls cutaneous Leishmaniasis.

<p>(<b>A</b>, <b>line graph</b>) BALB/c mice were injected with 2 mg of α-MRPs 8/14 one day before infection with <i>L. major</i> in the footpad and subsequent inoculation of the antibodies three times/week during four weeks after infection (…). Footpad sizes were measured every week for 8 weeks. (*) indicates significant difference P<0.01 between groups (n = 6). (<b>A, bar graph</b>) Parasites from footpads were extracted, and the parasitic burden was measured by limiting dilution assay, (*) denotes: P<0.05 between groups (n = 6). (<b>B, line graph</b>) BALB/c mice were injected with 10 µg of rMRPs 8/14 during 4 weeks (weeks 8 to12) directly into the infected footpad three times per week. Footpad sizes were measured every week for 12 weeks. (*) indicates significant difference P<0.01 between groups (n = 6). (<b>B, bar graph</b>) Parasites from footpads were extracted, and the parasitic burden was measured by limiting dilution assay, (*) denotes P<0.05 between groups (n = 6).