Cordycepin reduces β-catenin via proteasome dependent degradation.

<p>(A) U937 cells were treated with different concentrations (50 to 200 µM) of cordycepin. Nuclear and cytosolic fractions were extracted and the expression of β-catenin was determined by Western blot analysis. Actin and lamina/C were used as the loading control for cytosolic and nuclear fractions, respectively. (B) U937 cells were treated with 50 or 100 µM of cordycepin combined with/without MG-132 (10 µM) for 4 hrs. Expression levels of β-catenin were determined by Western blot analysis. Actin was used as a loading control.