Effects of CK2 inhibition on bortezomib-induced proteotoxic/ER stress.
- Sabrina Manni (127813)
- Alessandra Brancalion (463880)
- Elisa Mandato (463881)
- Laura Quotti Tubi (463882)
- Anna Colpo (463883)
- Marco Pizzi (463884)
- Rocco Cappellesso (384017)
- Fortunato Zaffino (463885)
- Speranza Antonia Di Maggio (463886)
- Anna Cabrelle (8735)
- Filippo Marino (463887)
- Renato Zambello (317614)
- Livio Trentin (317624)
- Fausto Adami (463888)
- Carmela Gurrieri (463889)
- Gianpietro Semenzato (287054)
- Francesco Piazza (378885)
Publication date
September 2013
DOIAbstract
<p>(A, B) Expression of Ire1α, phosphorylated Ser51 eIF2α (p-Ser51 eIF2α), total eIF2α in U-266 (A) and Granta-519 (B) cells treated with the CX-4945 and bortezomib (BZ in the figure) for 6h (A) and 18h (B). (C-E) Expression of poly-ubiquitin and Hsp70 in INA-6 (C), Granta-519 (D) and Rec-1 (E) cells treated with subtoxic and toxic doses of bortezomib for 18h and subsequently incubated with bortezomib and CX-4945 at different concentrations for additional 9 hours. βactin was used as a loading control.</p
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