Determination of IL-1β, and BDNF levels in the brain of CFA-treated mice: effects of treatment with bupropion and celecoxib.

<p>Effect of intraplantar injection of CFA (50 μl/paw) at 2 weeks: IL-1β levels in the (A) whole brain, (B) cortex and (C) hippocampus. Effect of treatment with celecoxib and bupropion both at (30 mg/kg, p.o, once a day, 7 days) and combined effect of bupropion plus celecoxib (3 mg/kg, p.o, once a day, 7 days). (D) BDNF levels in cortex. Effects of treatment with celecoxib and bupropion (both at 30 mg/kg, p.o, once a day, 7 days) and combination of bupropion and celecoxib (both at 3 mg/kg, p.o, once a day, 7 days). Each column represents the mean ± SEM of <i>4</i> animals per group. **P < 0.01 significantly different from Saline+Saline group, ^# P < 0.05 and ^{# #} P < 0.01 significantly different from CFA+Saline group (ANOVA followed by Bonferroni’s post-hoc test).