Treg from hi-dose sensitized mice adoptively transfers allergy modulation to low-dose sensitized mice.

<p>(<b>A</b>, <b>B</b>) Low-dose intraperitoneal sensitized mice were adoptively transferred with Treg (5 x 10⁵) from hi-dose versus low-dose intraperitoneal sensitized mice. Low-dose intraperitoneal sensitized mice without adoptive transfer were included as a control. All mice were challenged once/d and scored for clinical signs in a masked fashion approximately 20 min post challenge. Graph shows the results from one experiment (n=4/group), and is representative of 2 independent experiments. Statistical significance was computed via student’s t-test for low-dose sensitized mice transferred with lo-dose vs. hi-dose Treg (*p<0.05). (<b>C</b>) Adoptive transfer of Treg from hi-dose intraperitoneal sensitized mice conferred suppression of eosinophil infiltration. Each plot is derived from pooled conjunctivae of an n=4 per group. Data presented is from one experiment, which is representative of two independent experiments.