Phylogenetic tree and synteny of CYP3A genes.

<p>(A) Phylogeny of CYP3 amino acid sequences from chicken, zebra finch, turkey, and human. The maximum likelihood tree was created using MEGA5 software. The numbers on the branches indicate the number of times per 100 bootstrap replicates that the branch appeared in the trees, estimated by a random resampling of the data. The scale bar represents 50 substitutions per 100 residues. (B) Avian species possessed two <i>CYP3A</i> genes, whereas humans possessed six genes including two pseudogenes. Although the loci of <i>CYP3A</i> genes were almost conserved between avian species and human, none of the avian <i>CYP3A</i> genes showed clear correspondence to any of the human <i>CYP3A</i> genes.