<p>A summary is shown of CEP adduct levels in rat retina following blue light exposure with or without pretreatment with AL-8309A (from Western analyses in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0076325#pone.0076325.s002" target="_blank">Figure S2</a>). Log<sub>10</sub> transformed CEP optical density measurements were normalized to the mean dark control per analysis, outliers were eliminated and average ratios were transformed to linear scale. Δ represents the difference in average ratios between animals groups, the p-values are from the 2-sided t-test and error bars reflect standard deviation. The number of animals assayed in each group is indicated (n).</p
<p>Wholemount of the fellow-right (unexposed) (A,A′) and the left (light exposed) (B,B′) retinas fro...
PurposeTo develop a retinal degeneration model with selective photoreceptor loss and RPE sparing, to...
<p>Western blot analysis of MDA adducts after 12 h blue light exposure and in controls. The blot was...
<p>A summary is shown of average CEP adduct levels in rat plasma following <i>in </i><i>vivo</i> blu...
receptor agonist., λ=450 nm). Animals were sacrificed immediately following light exposure and eyes...
Carboxyethylpyrrole (CEP) adducts are oxidative modifications derived from docosahexaenoate-containi...
<div><p>Background</p><p>Carboxyethylpyrrole (CEP) adducts are oxidative modifications derived from ...
<p>(A) A representative CEP Western blot of rat plasma is shown following in vivo blue light exposur...
<p>Representative immunohistochemical analyses of posterior globe sections with rabbit anti-CEP poly...
<p>(A-B) Representative photomicrographs of retinal sections from 3 dpi group with examples of TUNEL...
<p>Outline of the time frame, animals and techniques employed to investigate the effects of blue-lig...
PurposeTo develop a retinal degeneration model with selective photoreceptor loss and RPE sparing, to...
<p><b>A.</b> Western-blot analysis shows expression of recombinant XIAP. <b>B.</b> Caspase 3 activit...
<p>Immunostaining of CEP250 with rod photoreceptor marker rhodopsin (A) and acetylated α-tubulin (B)...
PurposeTo develop a retinal degeneration model with selective photoreceptor loss and RPE sparing, to...
<p>Wholemount of the fellow-right (unexposed) (A,A′) and the left (light exposed) (B,B′) retinas fro...
PurposeTo develop a retinal degeneration model with selective photoreceptor loss and RPE sparing, to...
<p>Western blot analysis of MDA adducts after 12 h blue light exposure and in controls. The blot was...
<p>A summary is shown of average CEP adduct levels in rat plasma following <i>in </i><i>vivo</i> blu...
receptor agonist., λ=450 nm). Animals were sacrificed immediately following light exposure and eyes...
Carboxyethylpyrrole (CEP) adducts are oxidative modifications derived from docosahexaenoate-containi...
<div><p>Background</p><p>Carboxyethylpyrrole (CEP) adducts are oxidative modifications derived from ...
<p>(A) A representative CEP Western blot of rat plasma is shown following in vivo blue light exposur...
<p>Representative immunohistochemical analyses of posterior globe sections with rabbit anti-CEP poly...
<p>(A-B) Representative photomicrographs of retinal sections from 3 dpi group with examples of TUNEL...
<p>Outline of the time frame, animals and techniques employed to investigate the effects of blue-lig...
PurposeTo develop a retinal degeneration model with selective photoreceptor loss and RPE sparing, to...
<p><b>A.</b> Western-blot analysis shows expression of recombinant XIAP. <b>B.</b> Caspase 3 activit...
<p>Immunostaining of CEP250 with rod photoreceptor marker rhodopsin (A) and acetylated α-tubulin (B)...
PurposeTo develop a retinal degeneration model with selective photoreceptor loss and RPE sparing, to...
<p>Wholemount of the fellow-right (unexposed) (A,A′) and the left (light exposed) (B,B′) retinas fro...
PurposeTo develop a retinal degeneration model with selective photoreceptor loss and RPE sparing, to...
<p>Western blot analysis of MDA adducts after 12 h blue light exposure and in controls. The blot was...