Inhibition of MIF attenuated MI-induced upregulation of MIF, MMP-9 and IL-6 by peripheral blood mononuclear cells (PBMCs).

<p>Increased mRNA (upper panels) and protein levels (bottom panels) of MIF, MMP-9 and IL-6 were observed in PBMCs from patients with MI at 72 h, while anti-MIF interventions either by MIF antagonist COR100140 (COR, 50 µM) or anti-MIF monoclonal antibody (mAb, 10 µg/ml) abolished upregulation of these pro-inflammatory mediators. n=10 for healthy controls (CTL). n=15 for admission (adm.) after MI and n=14 for 72 h MI groups. *<i>P</i>&lt;0.05 vs. CTL, † <i>P</i>&lt;0.05 vs. 72 h MI without intervention.