Anti-AT prophylaxis increases pro-inflammatory cytokine and chemokine levels in <i>S. aureus</i> infected skin lesions.

<p>BALB/c mice (n = 10) were immunized IP with anti-AT mAb 2A3 (▪) or isotype control R347 (□) at 10 mg/kg, and ID challenged 24 h later with WT SF8300 (5×10⁷ CFU). Skin lesions were harvested after 8 or 24 h, and homogenates analyzed by Milliplex for mediator content. Data were normalized to ng/mg total skin lesion. Data were analyzed by Dunnett test, and values were considered statistically different if p≤0.05.