DNA Methylation changes in rat <i>gria2</i> gene promoter 5
- Ziv M. Machnes (465705)
- Tony C. T. Huang (228705)
- Philip K. Y. Chang (465706)
- Raminder Gill (465707)
- Nicholas Reist (465708)
- Gabriella Dezsi (465709)
- Ezgi Ozturk (465710)
- Francois Charron (465711)
- Terence J. O’Brien (455893)
- Nigel C. Jones (260557)
- R. Anne McKinney (465712)
- Moshe Szyf (228712)
Publication date
October 2013
DOIAbstract
<div><p>‘ <b>region in epileptic and control rats and their correlation with seizures</b>. </p> <p>(A) Representative electrographic recording of a seizure with synchronous video using Compumedics software. (B) Physical map of the rat <i>gria2</i> promoter (+320 - -664). CpG sites are marked by balloons and predicted transcription factors common to the mouse and rat 5’ region (-562--664) are indicated above the physical map. (C) Correlation between bursting frequency and average methylation levels of the <i>gria2</i> 5’ region (p=0.006, Pearson’s r=0.7190, n=13). (D) mRNA <i>gria2</i> expression levels in control and KA treated rats measured by qPCR 10 weeks after initial SE. ***p<0.005.</p></div
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