(<i>R</i>)-DOI has no effect on inflammatory gene expression in the colon.

<p>In contrast to the results observed in the aortic arch and the small intestine, (<i>R</i>)-DOI has no anti-inflammatory effects in the colon. Representative results for <i>Mcp-1</i> are shown here. (SS = Saline/Saline control; ST = Saline/TNF-α; D3S = DOI (0.3 mg/kg)/saline; D1T = DOI (0.01 mg/kg)/TNF-α; D2T = DOI (0.1 mg/kg)/TNF-α; D3T = DOI (0.3 mg/kg)/TNF-α; 4 animals per treatment; error bars represent ± SEM).