MiR-21 expression is blocked by its antagomir before and after 3 h of reperfusion in IPost-mediated cardiac protection.

<p>(A) Diagrammatic drawing showing the four groups of mice with different treatments. (B) miR-21 was markedly inhibited by antagomir-21 at the onset of I/R injury as determined by qRT–PCR. (C) IPost-induced upregulation of cardiac miR-21 was inhibited by antagomir-21 after 3 h of reperfusion as determined by qRT–PCR. Data are expressed as mean±SEM, n=5; ^**<i>P</i><0.01 compared with I/R group; ^{# #}<i>P</i><0.01 compared with IPost+I/R group; ^{† †}<i>P</i><0.01 compared with Antagomir-21+IPost+ I/R group.