Cytokine production during USA300 infection contributes to pathology.

<p>(A) ELISA analysis of individual cytokines in BAL of WT and IL-28R^−/− mice. (B) Western blot analysis of MX1 expression in lungs of WT and IL-28R^−/− mice following 4 and 18 hours of infection with USA300. (C) Numbers (CFU) of USA300 recovered from the BAL of from PBS control and Anakinra pre-treated mice following an 18 hour infection. (D) Numbers of USA300 (CFU) recovered from the lung of from PBS control and Anakinra pre-treated mice following an 18 hour infection. (E) Trichrome stained lungs from PBS control and Anakinra pre-treated mice following and 18 hour USA300 infection (original magnification 100x, insert 400x). Data are representative of at least 2 independent experiments.