Stratifin association with plakophilin-3 limits the exchange of plakophilin-3 with the desmosomal plaque.

<p>The association of stratifin with plakophilin-3 occurs through phosphorylation of serine 285 and limits the ability of cytoplasmic plakophilin-3 to exchange with the plakophilin-3 present at the desmosome. Decreased plakophilin-3 exchange at the desmosome is correlated with increased desmosomal adhesion and decreased cell migration.